Daniela Hristov

1. Education

Sofia University St. Kliment Ohridski, Sofia – Bulgaria 

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2. Additional Education

•           09-19.06.2014 - Laboratory for Genetic Engineering and Biotechnology, MANU Isolation of DNA/RNA from biological material

•           20.06.-08.07.2014 - Laboratory for genetic engineering and biotechnology, MANU Protein methods for hemoglobinological analyzes (HPLC, alkaline denaturation, column chromatography)

•           01.09.-04.09.2014 - Laboratory for genetic engineering and biotechnology, MANU Polymerase chain reaction (PCR) and electrophoresis on agarose gel

•           05.09.-11.09.2014 - Laboratory for genetic engineering and biotechnology, MANU SNaPshot

•           12.09-18.09.2014 - Laboratory for genetic engineering and biotechnology, MANU Work with ABI Prism 3130 and 3500 genetic analyzers

•           19.09-02.10.2014 - Laboratory for genetic engineering and biotechnology, MANU Sequencing

•           08.04.2018 - KITAZATO training Training for cryopreservation of gametes and embryos

o          07.04.2020 - Cooper Surgical, Trophectoderm biopsy and tubing of cells for

o          preimplantation genetic testing

•           15.04.2020 - Biotek, Skopje, Preventive measures for personal protection and taking material for testing for COVID 19

•           25.06.2020 - BioMerieux, Italy Webinar: "The Role of RT-PCR & Serology Tests in the Diagnosis and Management of COVID-19 Patients"

•           21.07.2020 - Biosystems, Skopje, (Cvetanka Kulukovska), Introduction to the use of the device: Automatic extraction system - SaMag-12tm System

•           24-29.07.2020 - Biosystems, Skopje, (Katerina Popovska-Janković) Introduction to the use of the device:

o          29-30.07.2020- Polymerase chain reaction instrument in real time - 7500 Real-Time PCR System

o          09.03.2021- The IVF Company in partnership with University of Kent       IVF around the world series: Canada: The future of IVF

o          30.03.2021 - The IVF Company in partnership with University of Kent      Setting up a PGT service in IVF laboratory

•           07.04.2021 -CooperSurgical Webinar, What to expect from oocyte vitrification: an update from the clinic and the laboratory

•           20.04.2021      International IVF Initiative     Beauty is in the Eye of the Beholder-Human sperm morphology

•           12.09.2023      ESHRE course            Should psychological counselling be mandatory/routine in infertility care and ART?

•           27.09.2023      ESHRE course            Delivering bad news to patients: a word of advice for embryologists

•           26.10.2023      ESHRE course            Fertility education and reproductive decision-making: why, who, when and how?

•           10.11.2023      ESHRE course            Factoring genetics in the management of implantation and early pregnancy

•           23-24.11.2024 ESHRE Seminar         PGT troubleshooting from intake to follow up

•           09.02.2024      ESHRE course            Changing aspects of communication in fertility care: a guide for fertility staff

•           05.03.2024      ESHRE course            Spermatogonial stem cell transplantation or testicular tissue grafting: what is the best choice

•           24-27.05.2025-Attendance of European Human Genetics Conference, Milan, 

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3. Working experience

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4. Foreign languages

- English 

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5. Membership

- European Society of Human Reproduction and Embryology-ESHRE

- Safe Motherhood Committee of Republic of North Macedonia

- Macedonian Society for Human Reproductive Medicine 

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6. Publications

Author:

•         07.08.2025- Hristov, D., & Stojanov, D. (2025). The State-of-the-Art Review on FSHR, LHCGR, AR, ESR1, and ESR2 Key Mutations and Their Impact on the Effectiveness of Infertility Therapies—What We Know So Far. Receptors, 4(3), 16.

•         21.05.2025- Elsevier: Hristov D, Stojanov D, In silico report on five high-risk protein C pathogenic variants: G403R, P405S, S421N, C238S, and I243T,Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis,Volume 831,2025,111907,ISSN 0027-5107,

https://doi.org/10.1016/j.mrfmmm.2025.111907.

•         ...

6. Publications

Author:

•         07.08.2025- Hristov, D., & Stojanov, D. (2025). The State-of-the-Art Review on FSHR, LHCGR, AR, ESR1, and ESR2 Key Mutations and Their Impact on the Effectiveness of Infertility Therapies—What We Know So Far. Receptors, 4(3), 16.

•         21.05.2025- Elsevier: Hristov D, Stojanov D, In silico report on five high-risk protein C pathogenic variants: G403R, P405S, S421N, C238S, and I243T,Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis,Volume 831,2025,111907,ISSN 0027-5107,

https://doi.org/10.1016/j.mrfmmm.2025.111907.

•         26.06.2024 - MDPI : Hristov, D.; Stojanov, D. Exploring Regulatory Properties of Genes Associated with Nonsyndromic Male Infertility. Reprod. Med. 2024, 5, 136-153. https://doi.org/10.3390/reprodmed5030013

 

Co-Author:

 

•         2021 - S Stojkovska, G Dimitrov, Z Petanovski, D Shushleski, S Saltirovski, V Matevski, M Hadzi Lega, V Sotirovska, D Stojanovska, N Stamenkovska, E Petanovska Kostova, R Latifi Isaki. A novel method of treating ovarian infertility: Is platelet-rich plasma a new promising therapy in the future? MMP 2021.

•         2020 - Kostova EP, Sotirovska V, Stojanovska D, Prodanova I, Petanovski Z. Immature Ovarian Teratoma. Donald School J Ultrasound Obstet Gynecol 2020; 14 (4):359-363.

•          2020 - E Petanovska Kostova, V Sotiroska, G Dimitrov, S Stojkovska, M Hadzi Lega, D Stojanovska, N Stamenkovska, L Simjanovska, Z Petanovski. Different Timing of Adjuvant Low Dose hCG and GnRH Agonist Trigger Protocol, in OHSS High-Risk Patient with Peak E2 Level. Gynecol Obstet Reprod Med. 2020;26(0):000-000.

    

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7. Press

- 25.5.2021- Faktor zdravje – “IVF in Hospital Settings”- TV24 (https://youtu.be/3vHcUJN9r94?si=icuB42ZhjOWrFw9Y )

- 14.12.2021 – Faktor zdravje – “How to Successful In Vitro” - TV24 (https://youtu.be/_CrwzYF2i3g?si=I4K8BL25IRorrrg1 )

- 07.06.2022 – Faktor zdravje – “Diagnosis and Prevention of Infertility”- TV24 (https://youtu.be/70uFL8hzzHs?si=pLqJY1hD8BEnpPCl )

- 24.01.2024 – “Forums and internet articles about in-vitro are not professional literature and a place to gather opinions and experiences from, says Hristov, who is head of the in-vitro laboratory at Re-Medica.” – Skopjeinfo.mk (https://skopjeinfo.mk/forumi-i-internet-statii-za-vitro-ne-se-struchna-literatura-i-mesto-za-sobiranje-mislenje-i-iskustva)

-15.07.2024 – “PROEKT ZDRAVJE – RE-MEDICA- DETERMINING THE QUALITY OF GAMETES DURING IN VITRO FERTILIZATION”- NashaTV (https://youtu.be/6XdyMtf097Y?si=N4kaRauyoyNUPptQ )

- 24.02.2025 – “Interview with Daniela Hristov, Embryologist: In every embryo we see someone's dream - in every laboratory procedure there is a part of our heart” – Skopjeinfo.mk (https://skopjeinfo.mk/intervju-so-daniela-hristov-embriolog-vo-sekoj-embrion-gledame-nechij-son-vo-sekoja-laboratoriska )